Notable and novel scientific awards to celebrate. 

October 2024

New Federal Awards

 
Kale BongersInternal MedicineNIH K08
5 years
The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy
Andrean BurnettRadiation OncologyNIH R01
5 years
Inflammation and EGFR crosstalk in HNSCC Therapy
Qiang ZhangNeurologyNIH R01
5 years
Glycolysis and rodent models of Alzheimer's disease
Other Awards   
Alejandro Comellas FreymondInternal MedicineNational Jewish HealthGenetic Epidemiology of COPD (COPD Gene)
David DickensPediatricsGlaxoSmithKline, Inc.Phase 1/2 Dose Determination and Dose Expansion Study of Cobolimab in Combination with Dostarlimab in Pediatric and Young Adult Participants with Newly Diagnosed and Relapsed/Refractory Tumors (POPSTAR)
Jeremy GreenleeNeurosurgeryNorthwestern University Feinberg School of MedicineNeuronal and network mechanisms of electrocortical stimulation
Ali JabbariDermatologyAlmirallGene expression signatures and upstream drivers of collapse of hair follicle immune privilege
Douglas LauxInternal MedicineAscendis Pharma A/STransCon TLR7/8 Agonist in Combination with Pembrolizumab, TransCon TLR7/8 Agonist in Combination with TransCon IL-2 /, or Pembrolizumab Monotherapy as Neoadjuvant Therapy in Participants with Stage III-IVA Resectable Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)
Santiago Gutierrez Ortega (Contact PI)
Edgar Samaniego (MPI)
NeurologyPatient-Centered Outcomes Research InstituteDIRECT study
Sneha PhadkeInternal MedicineBoehringer Ingelheim Pharma GmbH & Co.Beamion BCGC-1: A Phase Ib dose escalation and Phase II dose optimization, randomized, open-label, multicenter trial of oral zongertinib (BI 1810631) in combination with intravenous trastuzumab deruxtecan (T-DXd) or in combination with intravenous trastu

September 2024

New Federal Awards

 
Georgina AldridgeNeurologyNIH RF1
3 years
Vulnerability of the ascending arousal network to alpha-synuclein pathology
Zuhair BallasInternal MedicineNIH S10
1 year
Imaging Cytometer (Equipment for Flow Cytometry)
Ruth Chimenti - Contact PI
Kathleen Sluka - MPI
James Holmes - MPI
 NIH R61
2 years
Development of diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain
Daniel CookInternal MedicineNIH K08
5 years
Inhibiting CD4+ Th2 development and function by CFTR activity
Camille Dunn-JohnsonOtolaryngologyNIH R01
5 years
The Effectiveness of Cochlear Implants in Real-World Settings for Mild Cognitive Impairment and Dementia in Older Adults with Age-Related Hearing Loss
John EngelhardtAnatomy and Cell BiologyNIH N92
4 years
National Ferret Resource & Research Center on Lung Disease - Federal Contract
Alicia Gerke - Contact PI
Alejandro Pezzulo - MPI
Internal MedicineNIH R56
1 year
The Role of Residential Bioaerosol Exposure in Pulmonary Sarcoidosis
Matthew HoffmanOtolaryngologyNIH R03
2 years
Characterizing the impact of presbyphonia on social interaction
Allison MomanyPediatricsNIH R00
3 years
Neonatal Stress in Very Preterm Infants: Longitudinal Effects on Epigenetics and Neurodevelopment
Christopher PetkovNeurosurgeryNIH U01
5 years
Laminar Circuit Motifs for Working Memory and Language: From Cells to Systems
Alexandra PetrucciNeuroscience & PharmacologyNIH F32
2 years
Lesion extent and seizure propagation pathways across acute infection and chronic epilepsy in an infection induced mouse model
Andrea WeberPsychiatryUS Dept of Health & Human Services
3 years
The Substance Use Disorder Training Expansion to Advance Multidisciplinary Services in Iowa (SUD-TEAMS-IA)
Aaron SchererInternal MedicineUS Dept of Health & Human Services, CDC
5 years
UI Advancing Research in Immunization Services Network Coordinating Center (Contact PI is in the College of Public Health and the award sits there as well)
Competitive Renewal   
Stephanie RadkeOBGynIowa Dept of Health & Human Services
6 years
Maternal Health Innovation
Other Awards   
Chandrikha ChandrasekharanInternal MedicineAstraZeneca LPRilvegostomig in Combination With Chemotherapy as Adjuvant Treatment After Resection of Biliary Tract Cancer With Curative Intent (ARTEMIDE-Biliary01)
David DickensPediatricsMerck Sharp & Dohme LLCInvestigational Agents in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors
Nabeel Hamzeh - Contact PI
Karin Hoth - MPI
Internal MedicineAnn Theodore FoundationThe Neurobiology of Cognitive Dysfunction in Patients with Sarcoidosis.
Mariia KumskovaInternal MedicineHemostasis & Thrombosis Research SocietyMechanism of bleeding in Ehlers-Danlos syndrome
Lama NoureddineInternal MedicineF. Hoffmann-La Roche LtdRO7434656, an antisense inhibitor of complement factor B, in patients with primary IgA nephropathy at high risk of progression
Kittika PoonsombudlertInternal MedicineIncyte CorporationA Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
Antonio SanchezInternal Medicine89bio, Inc.Pegozafermin in Subjects with Compensated Cirrhosis due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)
Mark SchultzPediatricsUniversity of Notre DameDeveloping mRNA therapeutics and biomarkers for GSD III
Adeyinka TaiwoInternal MedicineStanford UniversityTaiwo K12 - Diabetes-Docs: Physician-Scientist Career Development Program from Stanford
Chen TanInternal MedicineEurofins Viracor, LLCBK Virus In Renal Transplant
Ziying YanAnatomy and Cell BiologyUniversity of Kansas Center for Research, Inc.Development of novel approaches for gene editing therapies of cystic fibrosis
Hanna ZembrzuskaInternal MedicineNovartis Pharmaceuticals CorporationRapcabtagene autoleucel versus Standard of Care in patients suffering from systemic lupus erythematosus (SLE) with active, refractory lupus nephritis (LN)

August 2024

New Federal Awards

  
Zuhair BallasInternal MedicineNIH S10
1 year
Imaging Cytometer
James ByrneRadiation OncologyNIH DP2
3 years
Novel extremophile-inspired radioprotectants
Po Hien EarSurgeryDoD, CDMRP
2 years
Targeted approach of Nrf2 inhibition in neuroendocrine cancers
Jonah ElliffMicrobiologyNIH F30
4 years
Evaluating the impact of malaria on immunogenecity of the Ebola virus vaccine
Eric HoffmanRadiologyNIH S10
6 years
NAEOTOM Alpha Photon-Counting CT Scanner
David Kaczka - Contact PI
Emmanuel Akor - MPI
Daniel Meggo - MPI
AnesthesiaNSF
1 year
I-Corps: Translation Potential of a Low-cost Mechanical Ventilator for Underserved Communities
Thomas Kehl-FieMicrobiologyNIH R01
2 years
Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamily
Filiz KorkmazMicrobiologyNIH R00
3 years
Establishing Mechanisms of LOX-1 Dependent Immune Regulation During Pneumonia
Hongshuai LiOrthopedic SurgeryNIH R01
5 years
Role of FGF21 in DMD
Katherine MathewsPediatricsUS Dept of Health and Human Services, CDCSurveillance of Muscular Dystrophies Component A: Iowa MD STARnet Core Site
Wendy MauryMicrobiologyNIH UH2
2 years
Identifying placental tissue tropism and cellular mechanisms of Ebola Virus transmission from mother to fetus in pregnancy
Patrick McNamaraPediatricsNIH UG3
6 years
1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) - CCC
Aaron SeamanInternal MedicineUS Dept of Health and Human Services, CDC
5 years
University of Iowa Prevention Research Center for Rural Health
Jacob SimmeringInternal MedicineNIH K01
5 years
Remote monitoring using commercially available activity trackers and computer vision provides a holistic, low-cost assessment of Parkinson's disease symptoms
Jan WesselNeurologyNIH R21
2 years
The TMS-evoked potential as a measure of cortical excitation and inhibition during cognitive processes
Competitive Renewal   
David StoltzInternal MedicineCystic Fibrosis FoundationIowa Cystic Fibrosis Foundation Research & Development Program
Other Awards   
Eric Hoffman - Contact PI
Alejandro Comells Freymond, MPI
RadiologyUniversity of California San FranciscoSubPopulations and InteRmediate Outcomes in COPD (SPIROMICS) III
Douglas LauxInternal MedicineGlaxoSmithKline, Inc.Dostarlimab as Sequential Therapy after Chemoradiation in Participants with Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
  Merck Sharp & Dohme LLCNeoadjuvant and adjuvant V940 (mRNA-4157) in combination with pembrolizumab (MK- 3475) versus standard of care, and pembrolizumab monotherapy in participants with resectable locally advanced cutaneous squamous cell carcinoma
Katherine MathewsPediatricsLarimar Therapeutics, Inc.Jive: An Open-Label Extension Study to Assess the Long-term Efficacy, Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Subcutaneous CTI-1601 in Subjects with Friedreich's Ataxia
Peggy NopoulosPsychiatryAnonymous - DomesticScanlan Scobell Psychedelic Research
John RiethInternal MedicineAscentage Pharma Group, Inc.APG-115 as a monotherapy or in combination with pembrolizumab in patients with unresectable or metastatic melanomas or advanced solid tumors.
Antonio SanchezInternal MedicineBoehringer Ingelheim Pharmaceuticals, Inc.Multicenter, randomised, double-blind, placebo-controlled, 48-week, Phase III trial to evaluate the efficacy and safety of survodutide administered subcutaneously in participants with overweight or obesity and presumed or confirmed non-alcoholic steatohepatitis (NASH)
Jodi TatePsychiatryThe Molina Healthcare Charitable FoundationProject ECHO:  Iowa's IDD Complex Care Needs ECHO for Direct Care Professionals
Hanna ZembrzuskaInternal MedicineNovartis Pharmaceuticals CorporationRapcabtagene autoleucel versus rituximab treatment in participants with severe refractory diffuse cutaneous systemic sclerosis

July 2024

New Federal Awards

  
Amy ConradPediatricsNIH R01
4 years
Speech Development and Brain Structure/Function in Infants with Isolated Oral Clefts: Relationship Anesthesia Exposure and Oxygenation
Huxing CuiNeuroscience & PharmacologyNIH R01
5 years
Uncovering the role of hypothalamic ciliary cAMP signaling in sex-specific control of metabolic homeostasis
Chad GrueterInternal MedicineNIH R01
5 years
Mediator kinase regulation of cardiac transcription
Priya IssureeInternal MedicineNIH R35
5 years
Connecting epigenetic programming of T cells with molecular traits of the immune system in health and disease
Bradley JonesMicrobiologyNIH R03
2 years
Influence of an E. coli hyperadherent probiotic on Salmonella intestinal colonization
Louis KollingNeuroscience & PharmacologyNIH F32
1 year
Reversal of Tau Pathology to Rescue Serotonergic Function in Early Alzheimer's Disease
Balaji ManicassamyMicrobiologyNIH R01
5 years
Investigation of host glycan requirements for the transmission of influenza viruses at the human-animal interface
Paul McCrayPedicatricsNIH R03
1 year
Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation
Mark SchultzPediatricsNIH R35
5 years
Regulation and Mechanisms of ER Proteostasis
Sam StephensInternal MedicineNIH R01
3 years
Metabolic control of beta-cell secretory organelle function
Seth TomchikNeuroscience & PharmacologyDoD, CDMRP
3 years
Mechanisms of Neuronal Dysregulation Underlying Behavioral Alterations in Neurofibromatosis Type 1
Competitive Renewal   
Steven Lentz - Contact PI
Anil Chauhan - MPI
Internal MedicineNIH T32
5 years
Program in Hematology: Molecular & Cell Biology Blood Cells
Matthew PothoffNeuroscience & PharmacologyNIH R01
4 years
Regulation of Metabolism by FGF21
Daniel Tranel - Contact PI
Sheila Baker - MPI
Gordon Buchanan - MPI
NeurologyNIH T32
5 years
Neuroscience Training Program
Other Awards   
Umar FarooqInternal MedicineJanssen Research & Development, Inc.A Phase 1b Multicenter, Open-label, Study of JNJ-90014496, an Autologous CD19/CD20 Bi-specific CAR-T Cell Therapy in Adult Participants with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
Paul McCrayPediatricsEmily's EntourageEnhanced Airway Transduction and Therapeutic Cargo Delivery with novel AAV Capsid Variants
Mohammed MilhemInternal MedicineReplimune, Inc.A Randomized, Controlled, Multicenter, Phase 3 Clinical Study Comparing Vusolimogene Oderparepvec in Combination with Nivolumab Versus Treatment of Physician's Choice in Patients with Advanced Melanoma That Has Progressed on an Anti-PD-1 and an Anti-CTLA-4 Containing Treatment Regimen
Eric MouInternal MedicineBeiGene USAA Phase 3, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared with Venetoclax Plus Obinutuzumab in patients with previously untreated chronic Lymphocytic Leukemia
Christopher StrouseInternal MedicineJanssen Research & Development, Inc.A Phase 2, Open-label Study to Evaluate the Efficacy and Safety of Different Sequences of Ciltacabtagene Autoleucel (Cilta-cel), Talquetamab SC in Combination with Daratumumab SC (Tal-D) and Teclistamab SC in Combination with Daratumumab SC (Tec-D) Following Induction with Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) in Participants with Standard-risk Newly Diagnosed Multiple Myeloma
Yousef ZakhariaInternal MedicineKura OncologyPhase 1, First-in-Human, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of KO 2806 When Administered as Monotherapy and in Combination Therapy in Adult Patients with Advanced Solid Tumors
  Merck & Company, Inc.A Phase 3 Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Previously Treated With Next-generation Hormonal Agent (NHA) and Taxane-based Chemotherapy

June 2024

New Federal Awards

  
Sarah BeattiePediatricsNIH R21
2 years
HTS with Aspergillus fumigatus for novel, mold-active antifungals
Ruth ChimentiPhysical TherapyDoD, CDMRP
4 years
Expanding and Accelerating Access to Care for Achilles Tendinopathy through Self-management Rehabilitation Strategies
Martine DunnwaldAnatomy & Cell BiologyNSF
4 years
Formation and function of the periderm
Elissa FaroInternal MedicineNIH R01
5 years
Can an Evidence-Based Mental Health Intervention be Implemented into Preexisting Home Visiting Programs using Implementation Facilitation?
John HartyPathologyNIH R01
5 years
Brain T cell interactions in microbial experienced mice
  NIH R21
2 years
Brain T cell interactions in microbial experienced mice
Christopher PetkovNeurosurgeryNSF
4 years
Neural Mechanisms for Auditory Memory Sequencing and Prediction
Anjali SharathkumanPediatricsNIH R21
1.5 years
Epidemiology and Biosocial risk factors for adverse outcomes of COVID-19 in people with sickle cell disease : Analyses of national COVID surveillance registry
Daniel TranelNeurologyNIH T32
5 years
Understanding Health and Disease at the Behavioral-Biomedical Interface
Budd Tucker, Contact PI
Robert Mullins, MPI
OphthalmologyNIH R01
4 years
Sustained Treatment of Wet AMD
Jessica TuckerMicrobiologyNIH R21
2 years
Gammaherpesviruses induce transfer RNA cleavage
Other Awards   
James ByrneRadiation OncologyDr. Ralph and Marian Falk Medical Research TrustNovel materials to improve management of hypoxic tumors
Margaret ByrneInternal MedicineMerck & Company, Inc.Adjuvant V940 (mRNA-4157) Plus Pembrolizumab Versus Adjuvant Placebo Plus Pembrolizumab in Participants With Resected Stage II, IIIA, IIIB (N2) Non-small Cell Lung Cancer
Linda CadaretInternal MedicineGB002, Inc.PROSERA
Alejandro Comellas FreymondInternal MedicineDuke UniversityRECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Marlan Hansen, Contact PI
Matthew Howard, MPI
Samuel Young, MPI
OtolaryngologyM34 Inc.Recombinant AAV capsid library screening to identify clinically relevant capsid variants in humans
Markus KuehnOpthalmologyBoehringer Ingelheim GmbHAMPK Activation for Neuroprotection in Glaucoma
Douglas LauxInternal MedicineGlaxoSmithKline LLCNovel Immunotherapy Combinations as First-Line Treatment in Participants with Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck
Lama NoureddineInternal MedicineAmgen, Inc.Avacopan in Subjects With Antineutrophil Cytoplasmic Antibody (ANCA)-associated Vasculitis
Tahaunty PenaInternal MedicineSanofi US Services Inc.Oral belumosudil in adult participants with chronic lung allograft dysfunction (CLAD) following bilateral lung tr
Michael ShyNeurologyElpida Therapeutics SPCA Prospective Natural History and Outcome Meausre Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
Ian ThornellInternal MedicineCystic Fibrosis FoundationCellular contributions to HEMT
Praveen VikasInternal MedicinePfizer, Inc.PF-07220060 PLUS FULVESTRANT COMPARED TO INVESTIGATOR'S CHOICE OF THERAPY IN PARTICIPANTS OVER 18 YEARS OF AGE WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE  ADVANCED/METASTATIC BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR CDK 4/6 INHIBITOR BASED THERAPY
Michael WendtInternal MedicineNovartis Pharmaceuticals CorporationImpact of Hypoxia on Lipid Metabolism in Obesity-Driven Breast Cancer Progression
Hanna ZembrzuskaInternal MedicineNovartis Pharmaceuticals CorporationIntravenous secukinumab infusion in adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR).

May 2024

New Federal Awards

  
Barry London, Contact PI
Bryan Allen, MPI
Internal MedicineNIH U01
3 years
Sex-dependent Impairment of Nitric Oxide Signaling and Mitochondrial Metabolism in Radiation-Induced Cardio-Pulmonary Dysfunction
Vincent Magnotta, Contact PI
Jacob Mathews, MPI
RadiologyNIH R01
5 years
High Resolution MRSI for Alzheimer's Disease and Related Dementias
Maria SpiesBiochemistryNIH T32
5 years
Iowa Biotech-TP: Predoctoral Program in Biotechnology
Colette GaletEmergency MedicineDHHS, Administration on Aging
3 years
Empowering Communities to Deliver and Sustain Evidence-Based Falls Prevention Programs
Hua SunPediatricsNIH R01
5 years
Targeting dynein-mediated trafficking in diabetic podocytopathy
Rebecca DoddInternal MedicineDod, CDMRP
3 years
Targeted Therapy for MPNST Metastasis
Competitive Renewal   
Vanessa Curtis, Contact PI
Thomas Scholz, MPI
PediatricsIowa DHHS
1 year
Pediatric Mental Health Care Access Program (PMHCAP)
Other Awards   
Carol JohnsonPediatricsIowa DHHS
5 years
Iowa Newborn Screening (NBS) Propel Project
Grerk SutamtewagulInternal MedicineKura Oncology
3 years
Venetoclax/azacitidine or venetoclax in combination with ziftomenib (KO-539) or standard induction cytarabine/daunorubicin (7+3) chemotherapy in combination with ziftomenib for the treatment of patients with acute myeloid leukemia
  Kura Oncology
3 years
 Ziftomenib Combinations for the Treatment of KMT2A-rearranged or NPM1-mutant Relapsed/Refractory Acute Myeloid Leukemia
Douglas LauxInternal MedicineRegeneron Pharmaceuticals, Inc.
3 years
REGN7075 (EGFRxCD28 costimulatory bispecific antibody) in combination with Cemiplimab in patients with advanced solid tumors.
David BenderOBGyNGOG Foundation
5 years
NXP800 in Subjects with Advanced Cancers and Expansion in Subjects with Ovarian Cancer
  GOG Foundation
3 years
VB10.16 Alone or in Combination with Atezolizumab in Patients with HPV16-Positive, PD-L1-positive, Recurrent or Metastatic Cervical Cancer who are Refractory to Pembrolizumab with Chemotherapy with/without Bevacizumab
Sam StephensInternal MedicineJuvenile Diabetes Research Foundation International
3 years
201311107-FY24 SRA: Role of -cell Golgi dysfunction in Type 1 diabetes pathogenesis
Christopher StrouseInternal MedicineJanssen Research and Development, LLC
2.5 years
Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants with High-Risk Multiple Myeloma

April 2024

New Federal Awards

  
Jing JiangPediatricsNIH R01
5 years
Mapping a Causal Prefrontal Pathway for Amygdala Modulation Utilizing Invasive and Noninvasive Brain Stimulation and Recording Methods in Humans
Marco HeftiPathologyNIH R01
5 years
A non-canonical role for tau in early human brain development
Budd TuckerOphthalmologyNIH R21
2 years
Label-free microfluidic isolation of patient iPSC-derived photoreceptor cells
Steven OfferPathologyNIH R01
2 years
A precision medicine approach to improve prediction of severe toxicity in fluorouracil chemotherapy
Competitive Renewals   
George RichersonNeruologyNIH R01
5 years
Inhibition of central CO2 chemoreception by seizures: Effects on ventilation, cardiovascular control and postictal recovery of consciousness
Other Awards   
Alejandro Comellas FreymondInternal MedicineKUMC
5 years
All of Us Research Program - Heartland Consortium
Erin ShriverOphthalmologyImmunovant Sciences, GmbH
5 years
Batoclimab for the Treatment of Participants with Active Thyroid Eye Disease (TED)
Yousef ZakhariaInternal MedicineAstellas Pharma Global Development, Inc
3 years
Batoclimab for the Treatment of Participants with Active Thyroid Eye Disease (TED)
Hanna ZembrzuskaInternal MedicineImmPACT Bio USA, Inc.
3 years
IMPT-514 in participants with active, refractory lupus nephritis and systemic lupus erythematosus
David BushnellRadiologyRayzeBio, Inc.
5 years
RYZ101 in combination with carboplatin + etoposide + atezolizumab in subjects with somatostatin receptor expressing (SSTR+) extensive stage small cell lung cancer (ES-SCLC)
Christopher StrouseInternal MedicineJanssen Research & Development, Inc
5 years
JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) Therapy Directed Against BCMA in Subjects with Multiple Myeloma
Tracey ChoNeurologySanofi US Services, Inc
5 years
Frexalimab (SAR441344) to Terifluomide (Aubagio) in Adult Participants with Relapsing Forms of Multiple Sclerosis
  Sanofi US Services, Inc
5 years
Frexalimab (SAR441344) to Placebo in Adult Participants with Nonrelapsing Secondary Progressive Multiple Sclerosis
Katherine MathewsPediatricsAvidity Biosciences, Inc
5 years
AOC 1044 Administered Intravenously to Healthy Adults
Val SheffieldPediatricsCRISPR Therapeutics, Inc
2 years
MYOC gene editing for Myocilin Associated Glaucoma

March 2024

New Federal Awards

  
Sandra BlomInternal MedicineNIH F31
3 years
GRASP55 Regulates Pancreatic Beta-cell Golgi Structure and Function During Cytokine Stress
Songhai Chen, Contact PI
Ronald Wiegel, MPI
Neuroscience & PharmacologyNIH R01
5 years
Role of the CTLH E3 ubiquitin ligase in breast cancer progression
Carl Andrew FrankAnatomy & Cell BiologyNIH R01
5 years
Synaptic defects caused by Mitochondrial Complex I dysfunction
Stephanie GantzPhysiologyNIH R01
5 years
Regulation of monoamine neurons by delta glutamate receptors
Lyndsay HarshmanPediatricsDoD, CDMRP
2 years
Women's Health in Tuberous Sclerosis Complex: A Population Based Assessment of Morbidity to Inform Clinical Care
Miriam McDonoughNeuroscience & PharmacologyNIH F31
3 years
Investigating the molecular mechanisms underlying aldosterone-mediated sodium appetite
Scott Moye-RowleyPhysiologyNIH R21
2 years
Novel mechanisms of azole resistance in clinical isolates of Candida glabrata
Krystal ParkerPsychiatryNIH R21
2 years
Roles of Descending Forebrain Pathways to the Cerebellum in Behavioral Timing
Mark SchultzPediatricsNIH R03
2 years
Investigating the importance of liver-specific glycans on NPC1 proteostasis
Hanna StevensPsychiatryNIH R01
3 years
Adolescent Insecticide Exposure and ADHD Risk: Mechanisms of Immediate Effects and Ongoing Vulnerability
Stefan StrackNeuroscience & PharmacologyDoD, CDMRP
2 years
Identifying temporal and spatial origins and reversibility in mouse models of neurodevelopmental disorders with autism
Ajit VikramInternal MedicineNIH R01
5 years
Glycopeptide vancomycin reshapes gut microbiota to mediate cardioprotective effects via microRNA-204
Jason WilkenPhysical TherapyDoD, CDMRP
2 years
The Effects of Heel Clearance on Foot Loading with Carbon Fiber Custom Dynamic Orthoses
Competitive Renewals   
Julien SebagPhysiologyNIH R01
4 years
Investigating the requirement of MRAP2 for ghrelin function
Maria SpiesBiochemistryNIH R35
5 years
Assembly and Dynamics of Molecular Machines in Genome Maintenance
Other Awards   
John BernatPediatricsDenali Therapeutics
5 years
DNL126 in pediatric participants with mucopolysaccharidosis type IIIA (Sanfilippo Syndrome Type A)
Marina Del Rios, Contact PI
Kari Harland, MPI
Emergency Medicine

Robert Wood Johnson Foundation

2 years

Innovation and Measurement of Pre-emptive Action on Racial Justice and Health Equity Curriculum Teaching (IMPACT)
Mohammed MilhemInternal MedicinePolaris Pharmaceuticals, Inc.
5 years
Placebo Plus Gemcitabine and Docetaxel in Previously Treated Subjects with Leiomyosarcoma (ARGSARC): A Randomized, Double-Blind, Multi-Center Phase 3 Trial
Antonio SanchezInternal MedicineGlaxoSmithKline, Inc.
3 years
GSK4532990   in   Adults   with pre-cirrhotic Non-Alcoholic Steatohepatitis (NASH)
Lane StrathearnPediatricsEarliTec Diagnostics, Inc.
5 years
Dynamic Quantification of Social-Visual Engagement (DQSVE) in Autism Spectrum Disorder (ASD): Diagnosis and Assessment For Children Ages 31 - 84 Months.
Christopher StrouseInternal MedicineJuno Therapeutics, Inc.
4 years
BMS-986393, a GPRC5D-directed CAR T Cell Therapy in Adult Participants with Relapsed or Refractory Multiple Myeloma
Grerk SutatewagulInternal MedicineMerk Sharp & Dohme, LLC
5 years
Nemtabrutinib Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in Participants With Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BELLWAVE-011)
Tomohiro TanakaInternal MedicineTakeda Development Center Americas, Inc.
5 years
Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease With METAVIR Stage F1 Fibrosis
Budd TuckerOphthalmologyGilbert Famiy Foundation
3 years
Development of novel next generation model systems for study and treatment of NF1
Yousef ZakhariaInternal MedicineArsenal Biosciences
3 years
AB-2100 in patients with recurrent advanced or metastatic clear-cell renal cell carcinoma.

February 2024

New Federal Awards          

  
Michael Anderson, Contact PI
Todd Scheetz, MPI
John Fingert, MPI
Physiology,
Ophthalmology
NIH R01
4 years
Foundational Biology of Glaucoma GWAS Loci
Denice Hodgson-Zingman, Contact PI
Leonid Zingman, MPI
Internal MedicineNIH R01
5 years
A New Pacing Approach for Cardiac Conditioning and Enhanced Cardioprotection
Emily AdelizziAnatomy & Cell BiologyNIH F31
3 years
Deciphering a tissue specific role for Arhgap29 during palatogenesis
Damian KrysanPediatricsNIH R01
5 years
REgulation of Candida albicans Pathogenesis by Protein Kinase and Transccription Factor
Sarah ShortInternal MedicineNIH K01
5 years
Antioxidant regulation of intestinal homeostasis and disease
Other Awards   
Don AndrsonOrthopedic SurgeryArthritis Foundation
2 years
Determining the traumatic origins of ankle OA and the time to joint degeneration
Tracey ChoNeurologyGenetech, Inc.
5 years
Satralizumab in patients with anti-n-methyl D aspartic acid receptor (NMDAR) or anti-leucine rich glioma inactivated 1 (LGI1)
Prajwal DhakalInternal MedicineNerviano Medical Sciences, S.r.l.
3 years
A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML
Douglas LauxInternal MedicineHoosier Cancer Research Network, Inc.
3 years
A Single Arm Phase II Study with Safety Run-in of Peptide Receptor Radionuclide Therapy (PRRT) in Combination with Immunotherapy for Patients with Merkel Cell Cancer (HCRN MCC20-443; iPRRT Study)
Melinda SeeringAnesthesiaHaisco-USA Pharmaceuticals, Inc.
5 years
A Global Multicenter, Randomized, Double-blinded, Propofol controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of HSK3486 Injectable Emulsion for Induction of General Anesthesia in Adults Undergoing Elective Surgery
Saima SharifInternal MedicinePDD Investigator Services, LLC
3 years
A Phase 2, Single-Arm, Open-Label Study with Dostarlimab Monotherapy in Participants with Untreated Stage II/III dMMR/MSI-H Locally Advanced Rectal Cancer

January 2024

New Federal Awards:

Patrick Sinn, Contact PI

Paul McCray, MPI

PediatricsNIH R01
​4 years
Adenine Base Edited Correction of Cystic Fibrosis Airways
Lane StrathearnPediatricsNIH R01
4.5 years
Perinatal Experience and Epigenetic Change in Autism: Discovering Modifiable Pathways for Intervention
Michael TomassonInternal MedicineUS National Science Foundation
1 year
I-Corps: A Home-based Solution for Remote Lung Function Monitoring for Patients with Chronic Lung Disease
Other Awards:   
Ted AbelNeuroscience & PharmacologyEagles Autism Foundation 
2 years
Characterizing the functional impact of mutations in Nr4a2-related Neurodevelopmental Syndrome
Huxing CuiNovo Nordisk Pharmaceuticals, IncNovo Nordisk Pharmaceuticals, Inc
2 years
Neural basis of metabolic control by ciliary cAMP signaling
Alina DumitrescuOphthalmologyJanssen Research & Development, Inc.
8 years
Global Patient Registry of Inherited Retinal Diseases
Rami El AbiadInternal MedicineSanofi US Services Inc.
3 years
Dupilumab Efficacy on Esophageal Function and Remodeling in Adult Participants with Eosinophilic Esophagitis (EoE)
Umar FarooqInternal MedicineJanssen Research & Development, Inc. 
3 years
Global Patient Registry of Inherited Retinal Diseases
Mark GrannerNeurologyNeurona Therapeutics, Inc
4 years
A First-in-human (FIH) Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
Jon HoutmanMicrobiologyRoy J. Carver Charitable Trust
1 year
State-of-the-art multicolor cellscape imaging system by canopy biosciences.
Asad JavedInternal MedicineIDEAYA Biosciences Inc.
5 years
IDE196 (Darovasertib) in combination with Crizotinib versus investigator's choice of treatment as a first-line therapy in HLA-A2 negative metastatic uveal melanoma (DAR-UM-2)
Douglas LauxInternal MedicineRegeneron Pharmaceuticals, Inc.
5 years
A multicenter, open-label phase 2 study of intratumoral vidutolimod (CMP-001) in combination with inravenous cemiplimabin subjects with selected types of advanced or metastatic cancer.
Paul McCrayPediatricsCystic Fibrosis Foundation
2 years
005651G223 Adenine Base Editing Repair of a CFTR Nonsense Mutation
Mohammed MilhemInternal MedicineMerck Sharp & Dohme LLC
8 years
Adjuvant V940 (mRNA-4157) Plus Pembrolizumab Versus Adjuvant Placebo Plus Pembrolizumab in Participants With High-Risk Stage II-IV Melanoma
Dawn Quelle, Contact PI
Rebecca Dodd, MPI 
Neuroscience & Pharmacology,
Internal Medicine
Gilbert Family Foundation
3 years
Improving Immunotherapy in MPNSTs
Ziying YanAnatomy & Cell BiologyCystic Fibrosis Foundation
2 years
Developing Basal Cell Tropic Human Bocavirus for Applications in Airway Gene Editing
Yousef ZakhariaInternal MedicineBristol-Myers Squibb Company
5 years
A Phase 1/2 Study of BMS-986340 as Monotherapy and in Combination with Nivolumab or Docetaxel in Participants with Advanced Solid Tumors
    

 

 

Previous Awards:

2023
2022

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